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Procalcitonin (PCT)

PCT is an important indicator to evaluate the clinical progress and prognosis of severe inflammatory disease.

Procalcitonin Rapid Test

 Procalcitonin (PCT) is the precursor of calcitonin, and is normally produced in the C-cells of the thyroid gland.During systemic and severe infections, PCT is also produced rapidly in other tissues, and serum PCT concentrations increase to very high levels. Assicot et al first described PCT as an inflammation-induced protein in 1993. Since then, numerous clinical studies have demonstrated the utility of this marker. PCT is more specific for detecting bacterial infection than other inflammatory markers, such as C-reactive protein (CRP) and white blood cell counts (WBC), because viral infections, autoimmune and allergic disorders do not induce PCT.

Principle

Biologic. material Category Test duration Category
serum, plasma, whole blood IVD Other 15 min Cardiac

 The PCT Rapid Test Device (Whole Blood/Serum/Plasma) detects Procalcitonin through visual interpretation of color development on the internal strip. Anti-PCT antibodies are immobilized on the test region of the membrane. During testing, the specimen reacts with anti-PCT antibodies conjugated to colored particles and precoated on the sample pad of the test. The mixture then migrates through the membrane by capillary action, and interacts with reagents on the membrane. If there are sufficient PCT in the specimen, a colored band will form at the test region of the membrane. The presence of this colored band indicates a positive result, while its absence indicates a negative result. The appearance of a colored band at the control region serves as a procedural control, indicating that the proper volume of specimen has been added and membrane wicking has occurred.