CRP is an acute phase protein produced by hepatocytes in response to inflammatory stimuli.

C-reactive Protein Test (CRP)

C-reactive Protein (CRP) in patient’s sera has been found in association with acute infections, necrotic conditions and a variety of inflammatory disorders. There is a strong correlation between serum levels of CrP and the onset of the inflammatory process. Monitoring the levels of CrP in patient’s sera indicates the effectiveness of treatment and the assessment of patient recovery. It is used in particular to differentiate bacterial infections from virus infections.


Biologic. material Category Test duration Category
serum, plasma, whole blood IVD Other 15 min Inflammation

The CRP Test Device is an immunochromatographic test, based on two specific antibodies against human CRP. The concentration-dependent formation of test lines allows a rapid semi-quantitative determination of CRP in whole blood samples. 

The test device is applied with the test sample which is diluted with buffer solution. The sample now moves through the test strip. If the test sample contains CRP, it attaches to the first anti-CRP antibody which is conjugated with a red gold colloidal for color marking. The red CRP antibody-gold complex, together with the sample liquid, diffuses through the membrane that is pre dispensed with Test line of the second anti-CRP antibody. The CRP-antibody-gold complex is immobilized by the antibodies coated on the membrane leading to the formation of red lines.

The intensity of Test Line depends on the CRP concentration in the sample. A test band (T) signal weaker than the reference band (R) indicates that the CRP level in the specimen is between 10-30 mg/L. A test band (T) signal equal or close to the reference band (R) indicates that the CRP level in the specimen is approximately 30 mg/L. A test band (T) signal stronger than the reference band (R) indicates that the CRP level in the specimen is above 30 mg/L.

The appearance of a colored band at the control region serves as a procedural control, indicating that the proper volume of specimen has been added and membrane wicking has occurred.